Google Videos - Low Level Laser therapy
The laser beam is a stimulated electromagnetic emission of the light spectrum. The most frequently used low level laser therapy rays are these ...
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Fat-Specific DsbA-L Overexpression Promotes Adiponectin Multimerization and Protects Mice From Diet-Induced Obesity and Insulin Resistance.
Diabetes. 2012 Jul 17;
Liu M, Xiang R, Wilk SA, Zhang N, Sloane LB, Azarnoush K, Zhou L, Chen H, Xiang G, Walter CA, Austad SN, Musi N, Defronzo RA, Asmis R, Scherer PE, Dong LQ, Liu F
The antidiabetic and antiatherosclerotic effects of adiponectin make it a desirable drug target for the treatment of metabolic and cardiovascular diseases. However, the adiponectin-based drug development approach turns out to be difficult due to extremely high serum levels of this adipokine. On the other hand, a significant correlation between adiponectin multimerization and its insulin-sensitizing effects has been demonstrated, suggesting a promising alternative therapeutic strategy. Here we show that transgenic mice overexpressing disulfide bond A oxidoreductase-like protein in fat (fDsbA-L) exhibited increased levels of total and the high-molecular-weight form of adiponectin compared with wild-type (WT) littermates. The fDsbA-L mice also displayed resistance to diet-induced obesity, insulin resistance, and hepatic steatosis compared with WT control mice. The protective effects of DsbA-L overexpression on diet-induced insulin resistance, but not increased body weight and fat cell size, were significantly decreased in adiponectin-deficient fDsbA-L mice (fDsbA-L/Ad(-/-)). In addition, the fDsbA-L/Ad(-/-) mice displayed greater activity and energy expenditure compared with adiponectin knockout mice under high-fat diet. Taken together, our results demonstrate that DsbA-L protects mice from diet-induced obesity and insulin resistance through adiponectin-dependent and independent mechanisms. In addition, upregulation of DsbA-L could be an effective therapeutic approach for the treatment of obesity and its associated metabolic disorders.
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California Womens Conference for Health and Wellness
 | California Womens Conference is a prolific "woman to woman" conference. This conference is about women's health and educating women about healthcare in California. Several panelists will discuss issues in healthcare and how women will be affected. Home healthcare companies will be exhibiting along with clinics, insurance companies and alternative medical practitioners. | Views: 0  0 ratings |
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Google Videos - Laser Acupuncture
www.lasertcm.sg shows you what is Laser Acupuncture all about, go to the site to find out more case studies and testimonials.
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